Corrigendum: Defective Acetylcholine Receptor Subunit Switch Precedes Atrophy of Slow-Twitch Skeletal Muscle Fibers Lacking ERK1/2 Kinases in Soleus Muscle
نویسندگان
چکیده
“This work was supported by National of Institute of Neurological Disorders and Stroke grant R21NS077177 and by Texas A&M Health Science Center funds to M.R. We thank N. Yumoto for AChR antibodies, J. Lawler for SOD2 antibodies, J. Samuel for access to a confocal microscope and R. Miranda for access to a real-time PCR machine. The MyHC and SV2 monoclonal antibodies developed by S. Schiaffino and K. Buckley were obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by The University of Iowa, Department of Biology, Iowa City, IA”.
منابع مشابه
Defective Acetylcholine Receptor Subunit Switch Precedes Atrophy of Slow-Twitch Skeletal Muscle Fibers Lacking ERK1/2 Kinases in Soleus Muscle
To test the role of extracellular-signal regulated kinases 1 and 2 (ERK1/2) in slow-twitch, type 1 skeletal muscle fibers, we studied the soleus muscle in mice genetically deficient for myofiber ERK1/2. Young adult mutant soleus was drastically wasted, with highly atrophied type 1 fibers, denervation at most synaptic sites, induction of "fetal" acetylcholine receptor gamma subunit (AChRγ), redu...
متن کاملModulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.
Skeletal muscle is composed of diverse fiber types, yet the underlying molecular mechanisms responsible for this diversification remain unclear. Herein, we report that the extracellular signal-regulated kinase (ERK) 1/2 pathway, but not p38 or c-Jun NH(2)-terminal kinase (JNK), is preferentially activated in fast-twitch muscles. Pharmacological blocking of ERK1/2 pathway increased slow-twitch f...
متن کاملMuscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions.
The Ras-extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway appears to be important for the development, maintenance, aging, and pathology of mammalian skeletal muscle. Yet no gene targeting of Erk1/2 in muscle fibers in vivo has been reported to date. We combined a germ line Erk1 mutation with Cre-loxP Erk2 inactivation in skeletal muscle to produce, for the first time, mice lacking...
متن کاملThe Effect of Intensive Endurance Activity on Myocyte Enhancer Factor 2C Gene Expression of Slow and Fast Twitch Muscles in Male Wistar Rats: An Experimental Study
Background and Objectives: Myocyte enhancer factor 2c activates the genes of the slow-twitch muscle, the muscle which plays role in endurance activity. Therefore, the aim of this study was to evaluate the effect of a program of intensive endurance activity on MEF2c gene expression in fast and slow twitch skeletal muscles in wistar rats. Materials and Methods: In this experimental study, 14 mal...
متن کاملاثر 10 هفته تمرین قدرتی بر میزان گیرندههای نیکوتینی استیلکولین عضلات اسکلتی کند و تند انقباض موشهای صحرایی
Introduction: This study aimed at determining the impact of strength training on the rate of Nicotinic Acetylcholine Receptor(nAChR) at fast and slow twitch skeletal muscles of rats. Methods: Ten Wistar rats were divided into two groups randomly: control group(n=5) and strength-training group(n=5) which the latter group participated in a 10-week strength-training program. The strength training...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2017